Continuous Manufacturing in Pharmaceutical Industry: How it Thrives Green Chemistry Principles
DOI:
https://doi.org/10.29356/jmcs.v69i4.2326Keywords:
Continuous manufacturing, green chemistry, pharmaceutical industry, drug manufacturing, flow processAbstract
Abstract. Green Chemistry is an approach that looks for a sustainable development, encouraging the industry to migrate towards cleaner and more efficient processes, reducing waste generation, and depleting carbon footprint. Continuous Manufacturing is an advanced production technology that has caught attention during the past decade because of its flexibility, agility and robustness; lately, some regulatory agencies have endorsed its implementation, but there are only a few cases of its actual applications in the manufacturing of drug substances and products. In the current paper, we review some examples available up to date in which continuous processes and green chemistry principles converge in the pharma-chemical & pharmaceutical industries in order to bring elements to understand the future of drug molecules and pharmaceutical products production.
Resumen. La Química Verde es un enfoque que busca un desarrollo sostenible, alentando a la industria a migrar hacia procesos más limpios y eficientes, reduciendo la generación de residuos y la huella de carbono. La Manufactura Continua es una tecnología de producción avanzada que ha llamado la atención durante la última década por su flexibilidad, agilidad y robustez; últimamente, algunas agencias reguladoras han avalado su implantación, pero sólo existen unos pocos casos de sus aplicaciones reales en la fabricación de fármacos y medicamentos. En el presente artículo, repasamos algunos ejemplos disponibles en los que convergen la manufacturas procesos continuos y los principios de la química verde en las industrias farmoquímica y farmacéutica, con el fin de aportar elementos para comprender el futuro de la producción de fármacos y productos farmacéuticos.
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