Physicochemical and Biopharmaceutical Evaluation of Casiopeina III-Ea, a New Compound with Antineoplastic Activity

  • Ines Fuentes Noriega National Autonomous University of Mexico
  • PhD National Autonomous University of Mexico, Mexico
  • M Sc National Autonomous University of Mexico
  • M Sc National Autonomous University of Mexico
  • PhD National Autonomous University of Mexico, Mexico
Keywords: Casiopeina III-Ea, physicochemical properties, IC50, MDCK cells, copper

Abstract

Abstract. In the present work, the physicochemical (pka, intrinsic solubility, Log D distribution coefficient) and biopharmaceutical characterization (IC50 studies in MDCK cells) of Casiopeina III-Ea, a Cu (II) mixed chelate compound, was carried out. These parameters will tell us about the behaviour of Casiopeina III-Ea, as a new antineoplastic agent, in physiological media. This basic research of the Faculty of Chemistry of the UNAM, is directed towards the maturation of a technology, which consists of the pharmaceutical development of an antineoplastic copper coordination compound Casiopeina III-Ea.

 

Resumen. En el presente trabajo se realizó la caracterización fisicoquímica (pka, solubilidad intrínseca, coeficiente de distribución Log D) y biofarmacéutica (estudios IC50 en células MDCK) de Casiopeina III-Ea, un nuevo compuesto quelato mixto de cobre (II). Estos parámetros nos dirán mucho sobre el comportamiento de Casiopeina III-Ea, como un nuevo agente antineoplásico, en medios fisiológicos. Esta investigación básica de la Facultad de Química de la UNAM, está dirigida hacia la maduración de una tecnología, que consiste en el desarrollo farmacéutico de un compuesto de coordinación antineoplásico de cobre Casiopeina III-Ea.

Author Biographies

Ines Fuentes Noriega, National Autonomous University of Mexico

Department of Pharmacy, Building E, Faculty of Chemistry

PhD, National Autonomous University of Mexico, Mexico

Department of Inorganic and Nuclear Chemistry, Building B

M Sc, National Autonomous University of Mexico

Department of Pharmacy, Building E, Faculty of Chemistry

M Sc, National Autonomous University of Mexico

Department of Inorganic and Nuclear Chemistry, Building B

PhD, National Autonomous University of Mexico, Mexico

Emeritus National Researcher
Faculty of Chemistry
Inorganic and Nuclear Chemistry Department
Coordinator of the series "Science beyond the classroom"

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Published
07-01-2021