Fast and Green Method to Synthesis of Quinolone Carboxylic Acid Derivatives Using Giant-Ball Nanoporous Isopolyoxomolybdate as Highly Efficient Recyclable Catalyst in Refluxing Water


  • Yahya Mirzaie Payame Noor University
  • Jalil Lari Payame Noor University
  • Hooshang Vahedi Payame Noor University
  • Mohammad Hakimi Payame Noor University
  • Ahmad Nakhaei Islamic Azad University
  • Abdolreza Rezaeifard University of Birjand



Fluoroquinolone derivatives, fast and green synthesis, Keplerate {Mo132}


Various potentials antibacterial fluoroquinolone compounds were prepared by the direct amination of 7-halo-6- fluoroquinolone-3-carboxylic acids with variety of piperazine derivatives and (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b] pyridine using (NH4)42 [MoVI72MoV60O372(CH3COO)30(H2O)72], a Keplerate-type giant-ball nanoporous isopolyoxomolybdate, as a catalyst in refluxing water. The results showed that this catalyst acts as effective catalyst and the reaction proceeded more easily and gave the highest yields of the products in short reaction time under refluxing water. Short reaction times, simple isolation of the products, and usage of eco-friendly catalysts are some features of this procedure. In addition, the catalysts was easily recovered and used in multiple catalytic cycles. This material was prepared according to a previously published literature procedure using inexpensive and readily available starting materials.


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Author Biographies

Yahya Mirzaie, Payame Noor University

Department of Chemistry

Jalil Lari, Payame Noor University

Department of Chemistry

Hooshang Vahedi, Payame Noor University

Department of Chemistry

Mohammad Hakimi, Payame Noor University

Department of Chemistry

Ahmad Nakhaei, Islamic Azad University

Young Researchers and Elite Club, Mashhad Branch

Abdolreza Rezaeifard, University of Birjand

Catalysis Research Laboratory, Department of Chemistry, Faculty of Science






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