Identification, synthesis and structure assignment of two impurities of Erlotinib, a drug used for the treatment of some types of cancer.

María Guadalupe Morales-Vilchis; Patricia Flores-Sánchez; Jaime Escalante

doi:10.29356/jmcs.v63i1.714

Identification, synthesis and structure assignment of two impurities of Erlotinib, a drug used for the treatment of some types of cancer.

Authors

María Guadalupe Morales-Vilchis Signa S.A de C.V.
Patricia Flores-Sánchez Signa S.A. de C.V.
Jaime Escalante Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos http://orcid.org/0000-0001-5485-0244

DOI:

https://doi.org/10.29356/jmcs.v63i1.714

Keywords:

Eritronib, Cancer, Isomers, Impurity

Abstract

In the synthesis and industrial production of Erlotinib, the formation of organic impurities has been detected, so the identification and control of these is a critical point within the process. Standards for the consumption of pharmaceutical products are well established for active substances. In this sense, the synthesis and unequivocal identification of two impurities of Erlotinib as structural isomers was developed in the present study. The structural characterization of both isomers was confirmed by ¹H and ¹³C-NMR as well as by their X-ray diffraction study.

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References

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Published

2019-04-24

Issue

Vol. 63 No. 1 (2019): Regular Issue

Section

Regular Articles

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