Preparation of poly(MPAEMA)/halloysite Nanocomposites and Investigation of Antiproliferative Activity
DOI:
https://doi.org/10.29356/jmcs.v65i2.1257Keywords:
Polymer/clay nanocomposite, organoclay, thermal stability, in-situ polymerization, HeLa cell line, antiproliferative activityAbstract
Abstract. In this present work, the synthesis, characterization, and thermal properties of poly(2-(4-methoxyphenylamino)-2-oxoethyl methacrylate) (MPAEMA) polymer/clay-based nanocomposites were investigated by in-situ polymerization. At the characterizations of nanomaterials FTIR, XRD, SEM, and TGA techniques were used. It was determined from XRD and SEM measurements that the morphology of nanocomposites was exfoliated when the clay content in the polymer matrix was kept at 3% and 5%. From thermal analysis, a positive correlation was observed between the clay ratio and thermal stability of nanomaterials. Also, the cytotoxic effect of halloysite and its nanocomposites was investigated using XTT assay on HeLa cells. According to the results, nanocomposites showed a non-cytotoxic response and thus they may use safety in many research areas such as medicine, agriculture, cosmetics.
Resumen. En este trabajo, se reporta la síntesis, caracterización y propiedades térmicas de nanocompuestos de polímero / arcilla poli(2-(4-metoxifenilamino)-2-oxoetil metacrilato) (MPAEMA), obtenidos mediante polimerización in situ. Para caracterizar los nanomateriales se utilizaron las siguientes técnicas: FTIR, XRD, SEM y TGA. A partir de las mediciones de XRD y SEM se determinó que la morfología de los nanocompuestos muestra exfoliación, cuando el contenido de arcilla en la matriz de polímero se mantiene en 3% y 5%. Estudios mediante análisis térmico muestran una correlación positiva entre la relación de arcilla y la estabilidad térmica de los nanomateriales. También se investigó el efecto citotóxico de la halloysita y sus nanocompuestos utilizando el ensayo XTT en células HeLa. Los resultados muestran que los nanocompuestos tienen una respuesta no citotóxica y, por lo tanto, pueden utilizarse con seguridad en muchas áreas de investigación en disciplinas como la medicina, la agricultura y la cosmética.
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