essential oil; lavender; antimicrobial activity; bioactive compound; GC-MS; Mycobacterium smegmatis.


  • María del Rayo Camacho-Corona Universidad Autónoma de Nuevo León
  • Patricia C. Esquivel-Ferriño Universidad Autónoma de Nuevo León
  • Aldo F. Clemente-Soto Universidad Autónoma de Nuevo León
  • Mayela Y. Ramírez-Cabriales Universidad Autónoma de Nuevo León
  • Elvira Garza-González Universidad Autónoma de Nuevo León
  • Laura Alvarez Universidad Autónoma del Estado de Morelos



Citrus sinensis, GC-MS, Mycobacterium tuberculosis, anti-TB compounds


Tuberculosis (TB) is a great cause of morbidity and mortality around the world. The increasing incidence of multidrug-resistant (MDR) Mycobacterium tuberculosis and co-infection TB-AIDS led to the need to develop new TB drugs, and plants could be a source of them. The hexane extract of Citrus sinensis with anti-TB activity was analyzed by GC-MS. This analysis showed the presence of 40 volatile components, including monoterpenes (81.74%), sesquiterpenes (1.32%), fatty acids (1.15%), and some other oxygenated non-aromatic compounds (15.73%). Some identified compounds were tested against M. tuberculosis H37Rv, and one clinical isolated MDR M. tuberculosis strain. Results showed that palmitic acid, decanal, caryophyllene oxide, and cis-limonene oxide contributed to the anti-TB activity of hexane extract of C. sinensis peel.


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Author Biographies

María del Rayo Camacho-Corona, Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas

Patricia C. Esquivel-Ferriño, Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas

Aldo F. Clemente-Soto, Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas

Mayela Y. Ramírez-Cabriales, Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas

Elvira Garza-González, Universidad Autónoma de Nuevo León

Servicio de Gastroenterología y Departamento de Patología Clínica, Hospital

Laura Alvarez, Universidad Autónoma del Estado de Morelos

Centro de Investigaciones Químicas


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