Preparation of Ethyl Cellulose Nanoparticles by Solvent-Displacement Using the Conventional Method and a Recirculation System
DOI:
https://doi.org/10.29356/jmcs.v59i3.32Keywords:
ethyl cellulose, polymeric nanoparticles, solvent-displacement method, optimization, recirculation deviceAbstract
Ethyl cellulose polymeric nanoparticles (NPs) were prepared using the solvent-displacement technique with ethanol as the solvent. Optimization of the method included evaluating stirring rate and stabilizer type. NPs of 142.1 to 226.5 nm were obtained in a reproducible and efficient way (95% process efficiency) and with good stability (at room temperature). Moreover, a recirculation device was used in order to obtain concentrated NPs dispersions by a continuous process with potential scale-up. This method was challenged to encapsulate a hydrophilic antiviral model molecule (glycyrrhizinic acid) resulting in low entrapment efficiencies (approximately 1%).
The results indicate that NPs are obtained using this simple, economical process that offers the possibility to transport different agents for applications in food-processing, cosmetics production or pharmaceutical products.
Downloads
References
Minost, A.; Delaveau, J.; Bolzinger, M.A.; Fessi, H.; Elaissari, A. Recent Pat. Drug Deliv. Formul. 2012, 6, 250-258. DOI: https://doi.org/10.2174/187221112802652615
Kulterer, M. R.; Reischl, M.; Reichel, V. E.; Hribernik, S.; Wu, M.; Köstler, S.; Kargl, R.; Ribitsch, V. Colloids Surf. A: Physicochem. Eng. Aspects. 2011, 375, 23-29. DOI: https://doi.org/10.1016/j.colsurfa.2010.11.029
Beck-Broichsitter, M.; Rytting, E.; Lebhardt, T.; Wang, X.; Kissel, T. Eur. J. Pharm. Sci. 2010, 41, 244-253. DOI: https://doi.org/10.1016/j.ejps.2010.06.007
www.dow.com/dowwolff/en/pdf/192-00818.pdf Ethocel, Ethylcellulose polymers, Technical Handbook, accessed in July, 2014.
Tachaprutinun, A.; Udomsup, T.; Luadthong, Ch.; Wanichwecharungruang, S. Int. J. Pharm. 2009, 374, 119-124. DOI: https://doi.org/10.1016/j.ijpharm.2009.03.001
Sansukcharearnpon, A.; Wanichwecharungruang, S.; Leepipatpaiboon, N.; Kerdcharoen, T.; Arayachukeat, S. Int. J. Pharm. 2010, 391, 267-273. DOI: https://doi.org/10.1016/j.ijpharm.2010.02.020
Arias, J.L.; López-Viota, M.; López-Viota, J.; Delgado, A.V. Int. J. Pharm. 2009, 382, 270-276. DOI: https://doi.org/10.1016/j.ijpharm.2009.08.019
Piñón-Segundo, E.; Ganem-Quintanar, A.; Garibay-Bermúdez, J.R.; Escobar-Chávez, J.J.; López-Cervantes, M.; Quintanar-Guerrero, D. Pharm. Dev. Technology. 2006, 11, 493-501. DOI: https://doi.org/10.1080/10837450600940824
Quintanar-Guerrero, D.; Allémann, E.; Fessi, H.; Doelker, E. Drug Dev. Ind. Pharm. 1998, 24, 1113-1128. DOI: https://doi.org/10.3109/03639049809108571
Mendoza-Muñoz, N.; Quintanar-Guerrero, D.; Alléman, E. Recent Pat. Drug Deliv. Formul. 2012, 6, 236-249. DOI: https://doi.org/10.2174/187221112802652688
Bilati, U.; Allémann, E.; Doelker, E. Eur. J. Pharm. Sci. 2005, 24, 67-75. DOI: https://doi.org/10.1016/j.ejps.2004.09.011
Vitale, S.A.; Katz, J.L. Langmuir. 2003, 19, 4105-4110. DOI: https://doi.org/10.1021/la026842o
Ganachaud, F.; Katz, J.L. Chem. Phys. Chem. 2005, 6, 209-216. DOI: https://doi.org/10.1002/cphc.200400527
Mora-Huertas, C.E.; Fessi, H.; Elaissari, A. Adv. Colloid Interface Sci. 2011, 163, 90-122. DOI: https://doi.org/10.1016/j.cis.2011.02.005
Aschenbrenner, E.; Bley, K.; Koynov, K.; Makowski, M.; Kappl, M.; Landfester, K.; Weiss, C.K. Langmuir. 2013, 29, 8845-8855. DOI: https://doi.org/10.1021/la4017867
Aubry, J.; Ganachaud, F.; Cohen Addad, J-P.; Cabane, B. Langmuir. 2009, 25, 1970-1979. DOI: https://doi.org/10.1021/la803000e
Obolentseva, G.V.; Litvinenko, V.I.; Ammosov, A.S.; Popova, T.P.; Sampiev, A.M. Pharmaceut. Chem. J. 1999, 33, 24-31. DOI: https://doi.org/10.1007/BF02510095
Sun, Ch.; Xie, Y.; Tian, Q.; Liu, H. Colloids Surf. A. 2007, 305, 42-47. DOI: https://doi.org/10.1016/j.colsurfa.2007.04.056
Kvasni?ka, F.; Vold?ich, M.; Vyhnálek, J. J. Chromatogr. A. 2007, 1169, 239-242. DOI: https://doi.org/10.1016/j.chroma.2007.08.074
Fenwick, G.R. Food Chem. 1990, 38, 119-143. DOI: https://doi.org/10.1016/0308-8146(90)90159-2
Hernández Cerón, R. S. Bachelor´s Thesis, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Estado de México; 2013.
Quintanar-Guerrero, D.; Tamayo-Esquivel, D.; Ganem-Quintanar, A.; Allémann, E.; Doelker, E. Eur. J. Pharm. Sci. 2005, 26, 211-218. DOI: https://doi.org/10.1016/j.ejps.2005.06.001
Noriega-Peláez, E.K.; Mendoza-Muñoz, N.; Ganem-Quintanar, A.; Quintanar-Guerrero, D. Drug Dev. Ind. Pharm. 2011, 37, 160-166. DOI: https://doi.org/10.3109/03639045.2010.501800
Galindo-Rodríguez, S.; Allémann, E.; Fessi, H.; Doelker, E. Pharm. Res. 2004, 21, 1428-1439. DOI: https://doi.org/10.1023/B:PHAM.0000036917.75634.be
Quintanar-Guerrero, D.; Ganem-Quintanar, A.; Allémann, E.; Fessi, H.; Doelker, E. J Microencapsulation. 1998, 15, 107-119. DOI: https://doi.org/10.3109/02652049809006840
Heurtault, B.; Saulnier, P.; Pech, B.; Proust, J-E.; Benoit, J-P. Biomaterials. 2003, 24, 4283-4300. DOI: https://doi.org/10.1016/S0142-9612(03)00331-4
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
