Continuous Manufacturing in Pharmaceutical Industry: How it Thrives Green Chemistry Principles

Luis Alberto Aranda-Hernandez; Mariana Ortiz-Reynoso; María Magdalena García-Fabila; Alfonso Durán

doi:10.29356/jmcs.v69i4.2326

Continuous Manufacturing in Pharmaceutical Industry: How it Thrives Green Chemistry Principles

Authors

Luis Alberto Aranda-Hernandez Universidad Autónoma del Estado de México https://orcid.org/0009-0005-9840-8497
Mariana Ortiz-Reynoso Universidad Autónoma del Estado de México
María Magdalena García-Fabila Universidad Autónoma del Estado de México
Alfonso Durán Universidad Nacional Autónoma de México https://orcid.org/0000-0002-0419-2391

DOI:

https://doi.org/10.29356/jmcs.v69i4.2326

Keywords:

Continuous manufacturing, green chemistry, pharmaceutical industry, drug manufacturing, flow process

Abstract

Abstract. Green Chemistry is an approach that looks for a sustainable development, encouraging the industry to migrate towards cleaner and more efficient processes, reducing waste generation, and depleting carbon footprint. Continuous Manufacturing is an advanced production technology that has caught attention during the past decade because of its flexibility, agility and robustness; lately, some regulatory agencies have endorsed its implementation, but there are only a few cases of its actual applications in the manufacturing of drug substances and products. In the current paper, we review some examples available up to date in which continuous processes and green chemistry principles converge in the pharma-chemical & pharmaceutical industries in order to bring elements to understand the future of drug molecules and pharmaceutical products production.

Resumen. La Química Verde es un enfoque que busca un desarrollo sostenible, alentando a la industria a migrar hacia procesos más limpios y eficientes, reduciendo la generación de residuos y la huella de carbono. La Manufactura Continua es una tecnología de producción avanzada que ha llamado la atención durante la última década por su flexibilidad, agilidad y robustez; últimamente, algunas agencias reguladoras han avalado su implantación, pero sólo existen unos pocos casos de sus aplicaciones reales en la fabricación de fármacos y medicamentos. En el presente artículo, repasamos algunos ejemplos disponibles en los que convergen la manufacturas procesos continuos y los principios de la química verde en las industrias farmoquímica y farmacéutica, con el fin de aportar elementos para comprender el futuro de la producción de fármacos y productos farmacéuticos.

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Author Biographies

Luis Alberto Aranda-Hernandez, Universidad Autónoma del Estado de México

Faculty of Chemistry

Mariana Ortiz-Reynoso, Universidad Autónoma del Estado de México

Faculty of Chemistry

María Magdalena García-Fabila, Universidad Autónoma del Estado de México

Faculty of Chemistry

Alfonso Durán, Universidad Nacional Autónoma de México

Faculty of Chemistry

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