Chemical Constituents, Antimicrobial Activity and Nitric Oxide Production Inhibitory Activity of Essential Oil from the Leaves of Croton kongensis Gagnep. Collected from Two Different Locations in Vietnam
DOI:
https://doi.org/10.29356/jmcs.v68i3.2065Keywords:
Croton kongensis, anti-inflammatory, antimicrobial, chemical composition, volatile oilsAbstract
Abstract. In this study, essential oil from the leaves of Croton kongensis Gagnep. from two different locations in Thanh Hoa province, Vietnam, were obtained by hydrodistillation in a Clevenger-type apparatus and characterized by GC/MS analyses. The Nhu Xuan essential oil sample contained sabinene (52.17 %), (E)-caryophyllene (7.23 %), and linalool (6.33 %) as major components, while the Thuong Xuan essential oil sample contained sabinene (12.96 %), camphene (9.45 %), linalool (8.43 %), bornyl acetate (7.99 %), (E)-nerolidol (7.07 %), and (E)-caryophyllene (6.53 %). Both essential oil samples showed promising antimicrobial activity against four bacterial and four fungal strains using the broth microdilution method, with minimum inhibitory concentrations (MICs) ≤ 200 μg/mL. However, the Thuong Xuan essential oil sample exhibited a broader spectrum of antimicrobial activity than the Nhu Xuan essential oil sample. Furthermore, the anti-inflammatory potential study showed that the Thuong Xuan essential oil sample exhibited better inhibition of nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells than the Nhu Xuan essential oil sample, which has IC50 values of 97.32 and 172.67 µg/mL, respectively. These findings provide a theoretical foundation for further investigation and use of the essential oil from C. kongensis leaves in the pharmaceutical and food industries.
Resumen. En este estudio, el aceite esencial de las hojas de dos poblaciones de Croton kongensis Gagnep. colectadas en la provincia Thanh Hoa en Vietnam, fue obtenido por hidrodestilación mediante un aparato Clevenger, y las muestras fueron caracterizadas mediante el análisis de CG/EM. La muestra del aceite esencial proveniente de Nhu Xuan contenía sabineno (52.17%), (E)-cariofileno (7.23%), y linalool (6.33%) como constituyentes mayoritarios, mientras que la muestra proveniente de Thuong Xuan contenía sabineno (12.96%), canfeno (9.45%), linalool (8.43%), acetato de bornilo (7.99%), (E)-nerolidol (7.07%), y (E)-cariofileno (6.53%). Ambas muestras mostraron actividad antimicrobiana promisoria contra cuatro cepas bacterianas y cuatro cepas fúngicas, usando el método de microdilución del caldo, obteniendo concentraciones mínimas inhibitorias (MICs) ≤ 200 μg/mL, respectivamente. No obstante, el aceite esencial proveniente de Thuong Xuan mostró un espectro más amplio de actividad antimicrobiana con respecto a la muestra de Nhu Xuan. Además, el estudio del potencial anti-inflamatorio de los aceites esenciales indicó que la muestra de Thuong Xuan exhibió mejor inhibición de la producción de óxido nítrico inducida por lipopolisacáridos en células RAW264.7, con respecto a la muestra de Nhu Xuan, con valores de CI50 de 97.32 y 172.67, respectivamente. Estos hallazgos proporcionan un argumento teórico para investigaciones adicionales y para el uso del aceite esencial de las hojas de C. kongensis en las industrias farmacéutica y de alimentos.
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