Chemical Constituents of Egyptian Withania Somnifera Leaves and Fruits and their Anticholinesterase Activity


  • Rahma S. Mahrous Alexandria University
  • Hoda M. Fathy Alexandria University
  • RASHA M. ABU EL-KHAIR Alexandria University
  • ABDALLAH A. OMAR Alexandria University



Withaperuvin C, phyperunolide, vaccenolylmonoglyceride, anticholinesterase, withania


Seven compounds were isolated from the leaves and fruits of Egyptian Withania somnifera dunal, (Family: Solanaceae). The identity of the compounds based on their spectroscopic data were as follows: two withanolides; withaperuvin C (1), phyperunolideF (2) and four lipids;1,2-di-O-palmitoyl-3-O-(6´´´-sulfo-α-D-quinovopyranosyl)-glycerol (3), vaccenic acid (5), 1,3 dicaproyl,2-vaccenoyl-glycerol (6), vaccenolymonoglyceride (7) and β-sitosterol glucoside (4). All the isolated metabolites except (4) were reported for the first time from this plant. Besides, this is the first report for isolation of compounds (6, 7) in a pure form from a natural source. Different fractions of the fruits of the Egyptian plant were investigated for their anticholinesterase activities where the most potent ones found to be the aqueous, the light petroleum fraction in addition to a mixture of lipids.


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Author Biographies

Rahma S. Mahrous, Alexandria University

Department of Pharmacognosy, Faculty of Pharmacy

Hoda M. Fathy, Alexandria University

Department of Pharmacognosy, Faculty of Pharmacy

RASHA M. ABU EL-KHAIR, Alexandria University

Department of Pharmacognosy, Faculty of Pharmacy

ABDALLAH A. OMAR, Alexandria University

Department of Pharmacognosy, Faculty of Pharmacy


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