A Rapid, One-pot, Multi-component Route to 4,4’-(arylmethylene)bis(3methyl1-1-phenyl-H-pyrazol-5-ols)
DOI:
https://doi.org/10.29356/jmcs.v59i1.6Keywords:
Ce(SO4)2.4H2O, 4, 4'-arylmethylene-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols), heterogeneous catalyst, environmentally friendly, solvent-free conditionsAbstract
A new, efficient and environmentally benign protocol for the one-pot, multicomponent synthesis of 4,4'-arylmethylene-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) by condensation of aryl aldehydes, phenyl hydrazine and ethyl acetoacetate catalyzed by Ce(SO4)2.4H2O as an ecofriendly catalyst with high catalytic activity and reusability at 125 °C under solvent-free conditions is reported.
The reaction proceeds to completion within 5-12 min in 81-98% yield. This new green methodology is of interest due to minimizing the cost of operational hazards and environmental pollution, its excellent yields, short reaction time and high catalyst activity and reusability.
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