Substituted Pyridopyrimidinones. Part 3. Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2-a]pyrimidin-4-one


  • Mohamed Abass Ain Shams University
  • Mostafa M. Ismail Ain Shams University
  • Wafaa R. Abdel-Monem Ain Shams University
  • Aisha S. Mayas Ain Shams University



Pyrido[1,2-a]pyrimidinone, Ethers, Pyrazoles, Oxadiazolines, Pyrones


A series of novel bis-heterocyclic ethers, containing 4Hpyrido[1,2-a]pyrimidin-4-one along with other five and six-membered heterocyclic rings, was obtained utilizing ethyl [(4-oxo-4Hpyrido[1,2-a]pyrimidin-2-yl)oxy]acetate (1), [(4-oxo-4H-pyrido[1,2a]pyrimidin-2-yl)oxy]acetic acid (2) and/or [(4-oxo-4H-pyrido[1,2a]pyrimidin-2-yl)oxy]acetohydrazide (3). Reaction of ester 1 with some ortho-hydroxy-aldehydes furnished the corresponding pyridopyrimidyloxypyrones. Reaction of ester 1 or acid 2 with 1,2-diamines led to some imidazoles. Also, some pyrazole, triazole, and oxadiazoline derivatives have been prepared from hydrazide 3.


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Author Biographies

Mohamed Abass, Ain Shams University

Department of Chemistry, Faculty of Education

Mostafa M. Ismail, Ain Shams University

Department of Chemistry, Faculty of Education

Wafaa R. Abdel-Monem, Ain Shams University

Department of Chemistry, Faculty of Education

Aisha S. Mayas, Ain Shams University

Department of Chemistry, Faculty of Education


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